New Publication by Friederike Ebner et al.
News from Nov 26, 2021
Congratulations to Jun.-Prof. Dr. Friederike Ebner on the publication of the article:
"A Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in
Inflammatory Lung Disease"
published in the Journal of Immunology Research; vol. 2021, Artikel ID 6234836
For more information please refer to the doi: 10.1155/2021/6234836
complete list of authors: Ebner, F.; Lindner, K.; Janek, K.; Niewienda, A.; Malecki, P. H.; Weiß, M. S.; Sutherland, T. E.; Heuser, A.; Kühl, A. A.; Zentek, J.; Hofmann, A.; Hartmann, S.
Immunomodulation of airway hyperreactivity by excretory-secretory (ES) products of the first larval stage (L1) of the gastrointestinal nematode Trichuris suis is reported by us and others. Here, we aimed to identify the proteins accounting for the modulatory effects of the T. suis L1 ES proteins and studied six selected T. suis L1 proteins for their immunomodulatory
efficacy in a murine OVA-induced allergic airway disease model. In particular, an enzymatically active T. suis chitinase mediated amelioration of clinical signs of airway hyperreactivity, primarily associated with suppression of eosinophil recruitment into the lung, the associated chemokines, and increased numbers of RELMα+ interstitial lung macrophages.
While there is no indication of T. suis chitinase directly interfering with dendritic cell activation or antigen presentation to CD4 T cells, treatment of allergic mice with the worm chitinase influenced the hosts’ own chitinase activity in the inflamed lung. The three-dimensional structure of the T. suis chitinase as determined by high-resolution X-ray crystallography revealed high similarities to mouse acidic mammalian chitinase (AMCase) but a unique ability of T. suis chitinase to form dimers. Our data indicate that the structural similarities between the parasite and host chitinase contribute to the disease-ameliorating effect of the helminth-derived chitinase on allergic lung inflammation.