Schematic overview of the functions of intestinal eosinophilic granulocytes. (Click on the image for a detailed legend.)

Eosinophils support IgA-producing plasma cells in the lamina propria and antibody class switching to IgA in the Peyer’s patches. In addition, eosinophils are important for the maintenance of the small intestinal mucus layer and hence the epithelial barrier function.