This project investigates long-term neurological complications following neonatal infection with Listeria monocytogenes (Lm) in mice. By comparing infections with both wild-type and avirulent mutant strains, the study aims to assess chronic behavioural, cognitive, and memory-related effects in adult survivors.

Key objectives include:

• Defining functional consequences of early-life Lm infection
• Identifying neurological and behavioural sequelae
• Studying brain homeostasis, stress profiles, and cellular alterations
• Exploring cell tropism and how Lm affects specific neuronal cell types

Ultimately, the findings will inform termination criteria for future experiments, significantly improving animal welfare by refining the use of neonatal infection models.