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PD Dr. Jürgen Krücken

Project A5: Metabolism of macrocyclic lactones and benzimidazoles in parasitic nematodes: PhD students Esra Yilmaz (A5-1), Natalie Jakobs (A5-2) and Marta Muniz (A5-3).

Freie Universität Berlin

Department of Veterinary Medicine

Institute of Parasitology and Tropical Veterinary Medicine

Research interest:

  • Molecular Parasitology

Krücken J, Czirják GÁ, Ramünke S, Serocki M, Heinricht SK, Melzheimer J, Costa MC, Hofer H, Aschenborn OHK, Barker NA, Capodanno S, Madeira de Carvalho L, von Samson-Himmelstjerna G, East ML, Wachter B. (2021).
Genetic diversity of vector‑borne pathogens in spotted and brown hyenas from Namibia and Tanzania relates to ecological conditions rather than host taxonomy.
Parasit Vectors 14:328. doi: 10.1186/s13071-021-04835-x.


Louro M, Kuzmina TA, Bredtmann CM, Diekmann I, de Carvalho LMM, von Samson-Himmelstjerna G, Krücken J. (2021).
Genetic variability, cryptic species and phylogenetic relationship of six cyathostomin species based on mitochondrial and nuclear sequences.
Sci Rep 11:8245. doi: 10.1038/s41598-021-87500-8.


Gerhard AP, Krücken J, Neveu C, Charvet CL, Harmache A, von Samson-Himmelstjerna G. (2021).
Pharyngeal Pumping and Tissue-Specific Transgenic P-Glycoprotein Expression Influence Macrocyclic Lactone Susceptibility in Caenorhabditis elegans.
Pharmaceuticals 14:153. doi: 10.3390/ph14020153.


Diekmann I, Alnassan AA, Globokar M, Pantchev N, Kurzrock L, Hernandez L, Lopez J, Ruano R, Herrero S, von Samson-Himmelstjerna G, Krücken J. (2020).
Canine Dracunculus Nematode Infection, Toledo, Spain.
Emerg Infect Dis 26:1860-3. doi: 10.3201/eid2608.201661.


Gerhard AP, Krücken J, Heitlinger E, Janssen IJ, Basiaga M, Kornaś S, Beier C, Nielsen MK, Davis RE, Wang J, von Samson-Himmelstjerna G. (2020).
The P-glycoprotein repertoire of the equine parasitic nematode Parascaris univalens
Sci Rep 10: 13586. doi: 10.1038/s41598-020-70529-6.


Yilmaz E, Fritzenwanker M, Pantchev N, Lendner M, Wongkamchai S, Otranto D, Kroidl I, Dennebaum M, Thanh H, Tran A, Ramünke S, Schaper R, von Samson-Himmelstjerna G, Krücken J. (2020).
Correction:The mitochondrial genomes of the zoonotic canine filarial parasites Dirofilaria (Nochtiella) repens and Candidatus Dirofilaria (Nochtiella) hongkongensis provide evidence for presence of cryptic species.
PLoS Negl Trop Dis 14:e0008347. doi: 10.1371/journal.pntd.0008347.


Bredtmann CM, Krücken J, Kuzmina T, Louro M, Madeira de Carvalho LM, von Samson-Himmelstjerna G. (2019).
Nuclear and mitochondrial marker sequences reveal close relationship between Coronocyclus coronatus and a potential Cylicostephanus calicatus cryptic species complex.
Infect Genet Evol Jul 9:103956. doi: 10.1016/j.meegid.2019.103956.


Yilmaz E, Gerst B, McKay-Demeler J, Krücken J. (2019).
Minimal modulation of macrocyclic lactone susceptibility in Caenorhabditis elegans following inhibition of cytochrome P450 monooxygenase activity.
Exp Parasitol 200:61-6. doi: 10.1016/j.exppara.2019.03.017.


Bredtmann CM, Krücken J, Murugaiyan J, Balard A, Hofer H, Kuzmina TA, von Samson-Himmelstjerna G. (2019).
Concurrent Proteomic Fingerprinting and Molecular Analysis Of Cyathostomins.
Proteomics Feb 20:e1800290. doi: 10.1002/pmic.201800290.


Yilmaz E, Wongkamchai S, Ramünke S, Koutsovoulos GD, Blaxter M, Popper S, Schaper R, von Samson-Himmelstjerna G, Krücken J. (2018).
High genetic diversity in the Dirofilaria repens species complex revealed by complete and partial mitochondrial genomes of canine and feline microfilaria samples from Thailand.
Transbound Emerg Dis 66: 389-99. doi: 10.1111/tbed.13033.


Bredtmann C, Krücken J, Murugaiyan J, Kuzmina T, von Samson-Himmelstjerna G. (2017).
Nematode Species Identification—Current Status, Challenges and Future Perspectives for Cyathostomins.
Front Cell Infect Microbiol 7: 283. doi: 10.3389/fcimb.2017.00283, PMCID: PMC5487379.


Yilmaz E, Ramünke S, Demeler J, Krücken J. (2017).
Comparison of constitutive and thiabendazole-induced expression of five cytochrome P450 genes in fourth-stage larvae of Haemonchus contortus isolates with different drug susceptibility identifies one gene with high constitutive expression in a multi-resistant isolate.
Int J Parasitol Drugs Drug Resist 7:362-9. doi: 10.1016/j.ijpddr.2017.10.001.


Yilmaz E, Fritzenwanker M, Pantchev N, Lendner M, Wongkamchai S, Otranto D, Kroidl I, Dennebaum M, Thanh H, Tran A, Ramünke S, Schaper R, von Samson-Himmelstjerna G, Krücken J. (2016).
The mitochondrial genomes of the zoonotic canine filarial parasites Dirofilaria (Nochtiella) repens and Candidatus Dirofilaria (Nochtiella) hongkongensis provide evidence for presence of cryptic species.
PLoS Negl Trop Dis 10:e0005028. doi:10.1371/journal.pntd.0005028. (GRK not acknowledged).


Maaz D, Rausch S, Richter D, Krücken J, Kühl AA, Demeler J, Blümke J, Matuschka FR, von Samson-Himmelstjerna G, Hartmann S. (2016).
Susceptibility to ticks and Lyme disease spirochetes is not affected in mice co-infected with nematodes.
Infect Immun 84:1274–86. doi: 10.1128/IAI.01309-15.

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