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Prof. Susanne Hartmann

Project B4: Effect of a previous protozoan infection with Toxoplasma co-infection prevents Th2 differentiation and leads to a helminth-specific Th1 response
PhD students: Norus Ahmed (B4-1), Benjamin Hamid (B4-2), Ankur Midha (associated 1)

Participating researcher in project B5: Differential instruction of Th2 cells during nematode and tick infections

Susanne Hartmann
Image Credit: Susanne Hartmann

Freie Universität Berlin

Department of Veterinary Medicine

Institute of Immunology

Speaker of the RTG 2046

Research interest:

  • Immunomodulation by parasites

(Stichtag: 15.10.2020)

Midha, A.; Ebner, F.; Schlosser-Brandenburg, J.; Rausch, S.; Hartmann, S. (2020)
Trilateral relationship: Ascaris, microbiota, and host cells.
Trends in parasitology, S. 2049
doi: 10.1016/j.pt.2020.09.002


Yordanova, I. A.; Lamatsch, M.; Kühl, A. A.; Hartmann, S.; Rausch, S. (2020)
Eosinophils are dispensable for the regulation of IgA and Th17 responses in Giardia muris infection.
Parasite Immunol, S. e12791
doi: 10.1111/pim.12791


Ebner, F.; Morrison, E.; Bertazzon, M.; Midha, A.; Hartmann, S.; Freund, C.; Álvaro-Benito, M. (2020)
CD4+ Th immunogenicity of the Ascaris spp. secreted products.
npj Vaccines; 5:25
doi: 10.1038/s41541-020-0171-z


Yordanova I.A.; Cortés A.; Klotz C., Kühl A.A.; Heimesaat M.M.; Cantacessi C.; Hartmann S.; Rausch S. (2019)
RORγt+ Treg to Th17 ratios correlate with susceptibility to Giardia infection.
Sci Rep 9(1), 20328
doi: 10.1038/s41598-019-56416-9


Delgado Betancourt, E.; Hamid, B.; Fabian, B. T.; Klotz, C.; Hartmann, S.; Seeber, F. (2019)
From Entry to Early Dissemination-Toxoplasma gondii's Initial Encounter With Its Host.
Front Cell Infect Microbiol.; 9:46.
doi: 10.3389/fcimb.2019.00046


French, T.; Düsedau, H. P.; Steffen, J.; Biswas, A.; Ahmed, N.; Hartmann, S.; Schüler, T.; Schott, B. H.; Dunay, I. R. (2019):
Neuronal impairment following chronic Toxoplasma gondii infection is aggravated by intestinal nematode challenge in an IFN-γ-dependent manner.
J. Neuroinflammation; 16(1), p. 159
doi: 10.1186/s12974-019-1539-8


Norus Ahmed, Nicole Affinass, Emanuel Heitlinger, Anja A. Kühl, Natasa Xenophontos, Victor H. Jarquin, Jenny Jost, Svenja Steinfelder, Susanne Hartmann (2019)
A novel non-invasive method to detect RELM beta transcript in gut barrier related changes during a gastrointestinal nematode infection.
Front. Immunol. 10:445
doi: 10.3389/fimmu.2019.00445


Venugopal, G.; O'Regan, N. L.; Babu, S.; Schumann, R. R.; Srikantam, A.; Merle, R.; Hartmann, S.; Steinfelder, S. (2019)
Association of a PD-L2 Gene Polymorphism with Chronic Lymphatic Filariasis in a South Indian Cohort.
Am J Trop Med Hyg. 100(2):344–350
doi: 10.4269/ajtmh.18-0731


Yordanova I*, Zakovic S*, Rausch S, CostaG, Levashina E, Hartmann S (2018):
Micromanaging immunity in the murine hosts versus mosquito vectors: microbiota-dependent immune responses to intestinal parasites. Frontiers Celluar Infection Microbiology, 8:308.
doi: 10.3389/fcimb.2018.0030


Aebischer, T.; Matuschewski, K.; Hartmann, S. (2018):
Editorial: Parasite Infections: From Experimental Models to Natural Systems.
Frontiers in cellular and infection microbiology; 8, S. 1–3
doi: 10.3389/fcimb.2018.00012, ISSN: 2235-2988


Affinass N, Löhning M, Hartmann S, Rausch S (2018)
Manipulation of the balance between Th2 and Th2/1 hybrid cells effects parasite nematode fitness.
European Journal of Immunology, European journal of immunology
DOI: 10.1002/eji.201847639 Pubmed: 30267404


Ugolini et al. …Ebner, FHartmann, S....... (2018):
Recognition of microbial viability via TLR8 drives TFHcell differentiation and vaccine responses.Nature immunology; 19(4), S. 386–396
DOI:10.1038/s41590-018-0068-4 ; PMID:29556002


Ahmed, N; French T, Rausch S, Kühl A, Hemminger K, Dunay I, Steinfelder S, Hartmann, S. (2017):
Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response.; Frontiers in cellular and infection microbiology; Volume 7(Article 341), S. 1–12
doi: 10.3389/fcimb.2017.00341; ISSN: 2235-2988


Bock, C.; Babu, S.; Breloer, M.; Rajamanickam, A.; Boothra, Y.; Brunn, M.-L.; Kühl, A. A.; Merle, R.; Löhning, M.; Hartmann, S.; Rausch, S. (2017):
Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells.; Front Cell Infect Microbiol; Vol. 7(Article 261), S. 1–15;
doi: 10.3389/fcimb.2017.00261


Ebner F, Kuhring M, RadonićA, Midha A, Renard B, Hartmann S. (2018).
Silent witness: Dual-species transcriptomics reveals epithelial immunological quiescence to helminth larval encounter and fostered larval development. Frontiers Immunology 9:1968. doi: 10.3389/fimmu.2018.01868.


Kofer, J; Hofer, H.; Hartmann, S. (2017):
Next-Generation Parasitologists: Structured Training Programs Meet Educational Challenges.
Trends in parasitology; 33(6), S. 423–425,
doi: 10.1016/j.pt.2017.03.008


Maaz, D.; Rausch, S; Richter, D; Krücken, J; Kühl, AA; Demeler, J; Blümke, J; Matuschka, F.-R.; Samson-Himmelstjerna, G. v.; Hartmann, S (2016):
Susceptibility to ticks and Lyme disease spirochetes is not affected in mice co-infected with nematodes.; Infection and immunity; 84(5), S. 1274–1286
doi: 10.1128/IAI.01309-15, Pubmed: 26883594


Midha, A.; Schlosser, J.; Hartmann, S. (2017):
Reciprocal Interactions between Nematodes and Their Microbial Environments.
Frontiers in cellular and infection microbiology; 7(Art. 144), S. 1–20
doi: 10.3389/fcimb.2017.00144, ISSN: 2235-2988


Midha A, Janek K, Niewienda A, Henklein P, Guenther S, Serra DO, Schlosser J, Hengge R, Hartmann S. (2018).The intestinal roundworm Ascaris suum releases antimicrobial factors which interfere with bacterial growth and biofilm formation.
Frontiers in cellular and infection microbiology.
doi: 10.3389/fcimb.2018.00271


Rausch S, Midha A, Kuhring M, Affinass N, Radonic A, Kühl AA, Bleich A, Renard BY, Hartmann S.(2018)
Parasitic nematodes exert antimicrobial activity and benefit from microbiota-driven support for host immune regulation. Submitted to Frontiers in Immunology
ISSN: 1521-4141, DOI: 10.1002/eji.201847639 Pubmed: 30267404

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