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Costanza Tacoli

Project B2-1: Evidence for Plasmodium falciparum artemisinin resistance in sub-Saharan Africa based on molecular markers and in vitro and in vivo findings

Costanza Tacoli
Image Credit: Costanza Tacoli

Oxford University, Hanoi, Vietnam

Lewycka lab

Oxford University Hanoi, Vietnam

Member: June 2015 - November 2019

Research interest
Plasmodium falciparum drug susceptibility analysed by in-vitro, ex-vivo assays, molecular biology

Title of PhD project
Reduced susceptibility to antimalarial drugs in Plasmodium spp

Supervisor
Prof. Dr. Frank P. Mockenhaupt

Bergmann C, van Loon W, Habarugira F, Tacoli C, Jäger JC, Savelsberg D, Nshimiyimana F, Rwamugema E, Mbarushimana D, Ndoli J, Sendegeya A, Bayingana C, Mockenhaupt FP. (2021).
Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda.
Emerg Infect Dis 27:294–6. doi: 10.3201/eid2701.203527.


Tacoli C, Gai PP, Siegert K, Wedam J, Kulkarni SS, Rasalkar R, Boloor A, Jain A, Mahabala C, Baliga S, Shenoy D, Gai P, Devi R, Mockenhaupt FP. (2019).
Characterization of Plasmodium vivax pvmdr1 polymorphisms in isolates from Mangaluru, India.
Am J Trop Med Hyg 101:416-7. doi: 10.4269/ajtmh.19-0224.


Wedam J, Tacoli C, Gai PP, Siegert K, Kulkarni SS, Rasalkar R, Boloor A, Jain A, Mahabala C, Baliga S, Shenoy D, Devi R, Gai P, Mockenhaupt FP (2018)
Molecular evidence for Plasmodium falciparum resistance to sulfadoxine-pyrimethamine but absence of K13 mutations in Mangaluru, southwestern India.
Am J Trop Med Hyg 99:1508-10. doi:10.4269/ajtmh.18-0549.


Esu E, Tacoli C, Gai P, Berens-Riha N, Pritsch M, Loescher T, Meremikwu M. (2018).
Prevalence of the Pfdhfr and Pfdhps mutations among asymptomatic pregnant women in Southeast Nigeria.
Parasitol Res 117:801-7. doi: 10.1007/s00436-018-5754-5.


Tacoli C, Gai PP, Bayingana C, Sifft K, Geus D, Ndoli J, Sendegeya A, Gahutu JB, Mockenhaupt FP. (2016).
Artemisinin resistance-associated K13 polymorphisms of Plasmodium falciparum in Southern Rwanda, 2010-2015.
Am J Trop Med Hyg 95:109093. doi: 10.4269/ajtmh.16-0483.

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