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Nicole Affinass

Project B5-1: Differential instruction of Th2 cells during nematode and tick infections

Nicole Affinass
Image Credit: Institut für Immunologie

Member: October 2015 - October 2019

Research interest
Immune response to parasites including Heligmosomoides polygyrus and Ixodes ricinus, functional characterization of Th2/1 cells

Title of PhD project
Functional characterization of Th2/1 hybrid CD4+ T cells induced in parasite infections

Prof. Susanne Hartmann and Dr. Sebastian Rausch

Ahmed N, Heitlinger E, Affinass N, Kühl AA, Xenophontos N, Jarquin VH, Jost J, Steinfelder S, Hartmann S. (2019).
A novel non-invasive method to detect RELM beta transcript in gut barrier related changes during a gastrointestinal nematode infection.
Front Immunol 10:445. doi: 10.3389/fimmu.2019.00445.

Affinass N, Zhang H, Löhning M, Hartmann S, Rausch S. (2018)
Manipulation of the balance between Th2 and Th2/1 hybrid cells effects parasite nematode fitness.
Eur J Immunol 48:1958-1964. doi: 10.1002/eji.201847639.

Rausch S, Midha A, Kuhring M, Affinass N, Radonic A, Kühl AA, Bleich A, Renard BY, Hartmann S. (2018).
Parasitic nematodes exert antimicrobial activity and benefit from microbiota-driven support for host immune regulation.
Front Immunol 9:2282. doi: 10.3389/fimmu.2018.02282.

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