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Nicole Affinass

Project B5-1: Differential instruction of Th2 cells during nematode and tick infections

Nicole Affinass
Image Credit: Institut für Immunologie

Member: October 2015 - October 2019

Research interest
Immune response to parasites including Heligmosomoides polygyrus and Ixodes ricinus, functional characterization of Th2/1 cells

Title of PhD project
Functional characterization of Th2/1 hybrid CD4+ T cells induced in parasite infections

Supervisors
Prof. Susanne Hartmann and Dr. Sebastian Rausch

Norus Ahmed, Nicole Affinass, Emanuel Heitlinger, Anja A. Kühl, Natasa Xenophontos, Victor H. Jarquin, Jenny Jost, Svenja Steinfelder, Susanne Hartmann (2019)
A novel non-invasive method to detect RELM beta transcript in gut barrier related changes during a gastrointestinal nematode infection.
Front. Immunol. 10:445
doi: 10.3389/fimmu.2019.00445


Affinass N, Löhning M, Hartmann S, Rausch S. (2018)
Manipulation of the balance between Th2 and Th2/1 hybrid cells effects parasite nematode fitness.
Eur J Immunol. 48:1958-1964
doi: 10.1002/eji.201847639


Rausch S, Midha A, Kuhring M, Affinass N, Radonic A, Kühl AA, Bleich A, Renard BY, Hartmann S(2018)
Parasitic nematodes exert antimicrobial activity and benefit from microbiota-driven support for host immune regulation.
Front Immunol. 9:2282
doi: 10.3389/fimmu.2018.02282

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