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Esra Yilmaz

Project A5: Metabolism of macrocyclic lactones and benzimidazoles in parasitic nematodes

Esra Yilmaz
Image Credit: Esra Yilmaz
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Member: April 2015 - November 2019

Research interest
drug resistance, cytochrome P450

Title of PhD project
Metabolism of macrocyclic lactones and benzimidazoles in parasitic nematodes

Supervisor
Dr. Jürgen Krücken


Jakobs N,Yilmaz E, Krücken J. (2022).
Transgenic Expression of Haemonchus contortus Cytochrome P450 Hco-cyp-13A11 Decreases Susceptibility to Particular but Not All Macrocyclic Lactones in the Model Organism Caenorhabditis elegans.
Int J Mol Sci 23:9155 doi: 10.3390/ijms23169155.


Yilmaz E, Fritzenwanker M, Pantchev N, Lendner M, Wongkamchai S, Otranto D, Kroidl I, Dennebaum M, Thanh H, Tran A, Ramünke S, Schaper R, von Samson-Himmelstjerna G, Krücken J. (2020).
Correction:The mitochondrial genomes of the zoonotic canine filarial parasites Dirofilaria (Nochtiella) repens and Candidatus Dirofilaria (Nochtiella) hongkongensis provide evidence for presence of cryptic species.
PLoS Negl Trop Dis 14:e0008347. doi: 10.1371/journal.pntd.0008347.


Yilmaz E, Gerst B, McKay-Demeler J, Krücken J. (2019).
Minimal modulation of macrocyclic lactone susceptibility in Caenorhabditis elegans following inhibition of cytochrome P450 monooxygenase activity.
Exp Parasitol 200:61-6. doi: 10.1016/j.exppara.2019.03.017.


Yilmaz E, Wongkamchai S, Ramünke S, Koutsovoulos GD, Blaxter M, Popper S, Schaper R, von Samson-Himmelstjerna G, Krücken J. (2019).
High genetic diversity in the Dirofilaria repens species complex revealed by complete and partial mitochondrial genomes of canine and feline microfilaria samples from Narathiwat, Thailand.
Transbound Emerg Dis 66:389-99. doi: 10.1111/tbed.13033.


Yilmaz E, Ramünke S, Demeler J, Krücken J. (2017).
Comparison of constitutive and thiabendazole-induced expression of five cytochrome P450 genes in fourth-stage larvae of Haemonchus contortus isolates with different drug susceptibility identifies one gene with high constitutive expression in a multi-resistant isolate.
Int J Parasitol Drugs Drug Resist 7:362-9. doi: 10.1016/j.ijpddr.2017.10.001.


Yilmaz E, Fritzenwanker M, Pantchev N, Lendner M, Wongkamchai S, Otranto D, Kroidl I, Dennebaum M, Thanh H, Tran A, Ramünke S, Schaper R, von Samson-Himmelstjerna G, Krücken J. (2016).
The mitochondrial genomes of the zoonotic canine filarial parasites Dirofilaria (Nochtiella) repens and Candidatus Dirofilaria (Nochtiella) hongkongensis provide evidence for presence of cryptic species.
PLoS Negl Trop Dis 10:e0005028. doi:10.1371/journal.pntd.0005028.

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