Member since: April 2021

Research interest

Protozoan parasites, Glycobiology, Antibody therapy, Nanobodies

Title of PhD project
Functionalization of single-chain antibodies for the treatment of severe parasitic diseases

Supervisor
Prof. Dr. Peter H. Seeberger and Dr. Oren Moscovitz

Lühle J, Seeberger PH, Moscovitz O (2026).
Cell surface thiol-disulfide regulation in cancer: Mechanisms, implications, and theranostic strategies.
Redox Biol 92:104142. doi: 10.1016/j.redox.2026.104142.

Lühle J, Krost S, Goerdeler F, Valentí A, Shanin E, Seitz C, Seeberger PH, Moscovitz O. (2025).
Bifunctional Cysteine-Engineered CAR‑T Cells Enable Thiol-Mediated Targeting to Overcome Antigen Escape in B Cell Lymphoma.
ACS Cent Sci 11:1852-1861. doi: 10.1021/acscentsci.5c00816.

Goerdeler F, Reuber EE, Lühle J, Leichnitz S, Freitag A, Nedielkov R, Groza R, Ewers H, Möller HM, Seeberger PH, Moscovitz O. (2023).
Thiol-Mediated Uptake of a Cysteine-Containing Nanobody for Anticancer Drug Delivery.
ACS Cent Sci 9:1111-8. doi: 10.1021/acscentsci.3c00177.

Khilji SK, Op 't Hoog C, Warschkau D, Lühle J, Goerdeler F, Freitag A, Seeberger PH, Moscovitz O. (2023).
Smaller size packs a stronger punch - Recent advances in small antibody fragments targeting tumour-associated carbohydrate antigens.
Theranostics 13:3041-3063. doi: 10.7150/thno.80901.

Khilji SK*, Goerdeler F*, Frensemeier K, Warschkau D, Lühle J, Fandi Z, Schirmeister F, Chen ZA, Turak O, Mallagaray A, Boerno S, Timmermann B, Rappsilber J, Seeberger PH, Moscovitz O. (2022).
Generation of glycan-specific nanobodies.
Cell Chem Biol Jun 6:S2451-9456(22)00199-4. doi: 10.1016/j.chembiol.2022.05.007.*equal contribution

Ben Ami Pilo H*, Khilji SK*, Lühle J*, Biskup K, Gal BL, Rosenhek Goldian I, Alfandari D, Revach OY, Kiper E, Morandi MI, Rotlopf R, Porat Z, Blanchard V, Seeberger PH, Regev-Rudzki N, Moscovitz O. (2022).
Sialylated N-glycans mediate monocyte uptake of extracellular vesicles secreted from Plasmodium falciparum-infected red blood cells.
J Extracellular Biol 1:e33. doi: 10.1002/jex2.33. *equal contribution