Springe direkt zu Inhalt

Nicole Affinass

Project B5-1: Differential instruction of Th2 cells during nematode and tick infections

Nicole Affinass
Image Credit: Institut für Immunologie

Member: October 2015 - October 2019

Research interest
Immune response to parasites including Heligmosomoides polygyrus and Ixodes ricinus, functional characterization of Th2/1 cells

Title of PhD project
Functional characterization of Th2/1 hybrid CD4+ T cells induced in parasite infections

Prof. Susanne Hartmann and Dr. Sebastian Rausch

Kapse B, Zhang H, Affinass N, Ebner F, Hartmann S, Rausch S. (2022).
Age-dependent rise in IFN-γ competence undermines effective type 2 responses to nematode infection.
Mucosal Immunol Jun 11. doi: 10.1038/s41385-022-00519-6.

Ahmed N, Heitlinger E, Affinass N, Kühl AA, Xenophontos N, Jarquin VH, Jost J, Steinfelder S, Hartmann S. (2019).
A novel non-invasive method to detect RELM beta transcript in gut barrier related changes during a gastrointestinal nematode infection.
Front Immunol 10:445. doi: 10.3389/fimmu.2019.00445.

Affinass N, Zhang H, Löhning M, Hartmann S, Rausch S. (2018)
Manipulation of the balance between Th2 and Th2/1 hybrid cells effects parasite nematode fitness.
Eur J Immunol 48:1958-1964. doi: 10.1002/eji.201847639.

Rausch S, Midha A, Kuhring M, Affinass N, Radonic A, Kühl AA, Bleich A, Renard BY, Hartmann S. (2018).
Parasitic nematodes exert antimicrobial activity and benefit from microbiota-driven support for host immune regulation.
Front Immunol 9:2282. doi: 10.3389/fimmu.2018.02282.

Banner Member of DRS