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Prof. Frank Seeber

Project C3: Role of immunity-related GTPases (IRGs) of wild rodents for maintaining virulent T. gondii genotypes in nature: PhD students: Francesca Torelli (C3-1), Benedikt Fabian (C3 associated 1), Estefania Delgado-Betancourt (C3-2) and David Warschkau (C3-3).

Frank Seeber
Image Credit: Frank Seeber

Robert Koch Institute

Mycotic and Parasitic Agents and Mycobacteria

Research interest:

  • Molecular Parasitology

Maus D, Curtis B, Warschkau D, Betancourt ED, Seeber F, Blume M. (2024.
Generation of Mature Toxoplasma gondii Bradyzoites in Human Immortalized Myogenic KD3 Cells.
Bio Protoc 14(1):e4916. doi: 10.21769/BioProtoc.4916.

Warschkau D, Seeber F. (2023).
Advances towards the complete in vitro life cycle of Toxoplasma gondii.
Fac Rev 12:1. doi: 10.12703/r/12-1.

Arranz-Solís D*, Warschkau D*, Fabian BT, Seeber F, Saeij JPJ. (2023).
Late Embryogenesis Abundant Proteins Contribute to the Resistance of Toxoplasma gondii Oocysts against Environmental Stresses.
mBio Feb 21:e0286822. doi: 10.1128/mbio.02868-22. *equal contribution

Warschkau D, Delgado Betancourt E, Holthaus D, Müller A, Kliem G, Krug SM, Schulzke JD, Aebischer T, Klotz C, Seeber F. (2022).
From 3D to 2D: Harmonization of Protocols for Two-dimensional Cultures on Cell Culture Inserts of Intestinal Organoids from Various Species.
Bio Protoc 12:e4295. doi: 10.21769/BioProtoc.4295.

Holthaus D, Delgado-Betancourt E, Aebischer T, Seeber F, Klotz C. (2021).
Harmonization of Protocols for Multi-Species Organoid Platforms to Study the Intestinal Biology of oxoplasma gondii and Other Protozoan Infections.
Front Cell Infect Microbiol 10:610368. doi: 10.3389/fcimb.2020.610368.

Fabian BT, Lepenies B, Schares G, Dubey JP, Spano F, Seeber F. (2021).
Expanding the Known Repertoire of C-Type Lectin Receptors Binding to Toxoplasma gondii Oocysts Using a Modified High-Resolution Immunofluorescence Assay.
mSphere 6:e01341-20. doi: 10.3390/ph1402015.

Fabian BT Hedar F, Koethe M, Bangoura B, Maksimov P, Conraths FJ, Villena I, Aubert D, Seeber F, Schares G. (2020).
Fluorescent bead-based serological detection of Toxoplasma gondii infection in chickens.
Parasit Vectors 13:388. doi: 10.1186/s13071-020-04244-6.

Delgado Betancourt E, Hamid B, Fabian BT, Klotz C, Hartmann S, Seeber F. (2019).
From Entry to Early Dissemination-Toxoplasma gondii's Initial Encounter With Its Host.
Front Cell Infect Microbiol 9:46. doi: 10.3389/fcimb.2019.00046.

Ferreira SCM*, Torelli F*, Klein S, Fyumagwa R, Hofer H, Seeber F, Karesh WB, East ML. (2018).
Evidence of high exposure to Toxoplasma gondii in free-ranging and captive African carnivores
Int J Parasitol Parasites Wildl 8:111-7. doi.org/10.1016/j.ijppaw.2018.12.007. *equal contribution

Torelli F, Zander S, Ellerbrok H, Kochs G, Ulrich RG, Klotz C, Seeber F. (2018).
Recombinant IFN-γ from the bank vole Myodes glareolus: a novel tool for research on rodent reservoirs of zoonotic pathogens.
Sci Rep 8: 2797. doi: 10.1038/s41598-018-21143-0, PMCID: PMC5809609.

Blume M, Seeber F. (2018).
Metabolic interactions between Toxoplasma gondii and its host.
F1000Res 7:F1000 Faculty Rev-1719. doi: 10.12688/f1000research.16021.1.

Ehret T, Torelli F, Klotz C, Pedersen AB, Seeber F. (2017).
Translational Rodent Models for Research on Parasitic Protozoa-A Review of Confounders and Possibilities.
Front Cell Infect Microbiol 7:238. doi: 10.3389/fcimb.2017.00238.

Seeber F, Steinfelder S. (2016).
Recent advances in understanding apicomplexan parasites.
F1000Res 5:F1000 Faculty Rev-1369. doi: 10.12688/f1000research.7924.1.

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