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Dr. Sebastian Rausch

Project B5: Differential instruction of Th2 cells during nematode and tick infections: PhD students: Nicole Affinass (B5-1), Ivet Yordanova (B5 associated 1), Bhavya Kapse (B5-2), Hongwei Zhang (B5 associated 2) and Joshua Adjah (B5-3).

Sebastian Rausch
Image Credit: Institut für Immunologie

Freie Universität Berlin

Department of Veterinary Medicine

Institute of Immunology

Research interest:

  • Infection Biology
  • Immunology

Kapse B, Zhang H, Affinass N, Ebner F, Hartmann S, Rausch S. (2022).
Age-dependent rise in IFN-γ competence undermines effective type 2 responses to nematode infection.
Mucosal Immunol Jun 11. doi: 10.1038/s41385-022-00519-6.

Zhang H, Bednář L, Heitlinger E, Hartmann S, Rausch S. (2022).
Whip- and pinworm infections elicit contrasting effector and distinct regulatory responses in wild house mice.
Int J Parasitol 52:519-24. doi: 10.1016/j.ijpara.2022.03.006.

Hamid B, Schlosser-Brandenburg J, Bechtold L, Ebner F, Rausch S, Hartmann S. (2021).
Early Immune Initiation by Porcine Cells following Toxoplasma gondii Infection versus TLR Ligation.
Microorganisms 9:1828. doi: 10.3390/microorganisms9091828.

Midha A, Ebner F, Schlosser-Brandenburg J, Rausch S, Hartmann S. (2021).
Trilateral relationship: Ascaris, microbiota, and host cells.
Trends Parasitol 37:251-62. doi: 10.1016/j.pt.2020.09.002.

Yordanova IA, Lamatsch M, Kühl AA, Hartmann S, Rausch S. (2021)
Eosinophils are dispensable for the regulation of IgA and Th17 responses in Giardia muris infection.
Parasite Immunol 43:e12791. doi: 10.1111/pim.12791.

Yordanova IA, Cortés A, Klotz C, Kühl AA, Heimesaat MM, Cantacessi C, Hartmann S, Rausch S. (2019).
RORγt+ Treg to Th17 ratios correlate with susceptibility to Giardia infection.
Sci Rep 9:20328. doi: 10.1038/s41598-019-56416-9.

Yordanova I*, Zakovic S*, Rausch S, CostaG, Levashina E, Hartmann S. (2018).
Micromanaging immunity in the murine hosts versus mosquito vectors: microbiota-dependent immune responses to intestinal parasites.
Front Cell Infect Microbiol 8:308. doi: 10.3389/fcimb.2018.00308. *equal contribution

Rausch S, Midha A, Kuhring M, Affinass N, Radonic A, Kühl AA, Bleich A, Renard BY, Hartmann S. (2018).
Parasitic nematodes exert antimicrobial activity and benefit from microbiota-driven support for host immune regulation. Front Immunol 9:2282. doi: 10.3389/fimmu.2018.02282.

Affinass N, Zhang H, Löhning M, Hartmann S, Rausch S. (2018).
Manipulation of the balance between Th2 and Th2/1 hybrid cells effects parasite nematode fitness.
Eur J Immunol 48:1958-64. doi: 10.1002/eji.201847639.

Ahmed N, French T, Rausch S, Kühl AA, Hemminger K, Dunay I, Steinfelder S, Hartmann S. (2017).
Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response.
Front Cell Infect Microbiol 7:341. doi: 10.3389/fcimb.2017.00341.

Bock,C, Babu S, Breloer M, Rajamanickam A, Boothra Y, Brunn ML, Kühl AA, Merle R, Löhning M, Hartmann S, Rausch S. (2017).
Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells
Front Cell Infect Microbiol 7:261. doi: 10.3389/fcimb.2017.00261.

Maaz D, Rausch S, Richter D, Krücken J, Kühl AA, Demeler J, Blümke J, Matuschka FR, von Samson-Himmelstjerna G, Hartmann S. (2016).
Susceptibility to ticks and Lyme disease spirochetes is not affected in mice co-infected with nematodes.
Infect Immun 84:1274–86. doi: 10.1128/IAI.01309-15.

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