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Dr. Sebastian Rausch

Project B5: Differential instruction of Th2 cells during nematode and tick infections: PhD students: Nicole Affinass (B5-1), Ivet Yordanova (B5 associated 1), Bhavya Kapse (B5-2), Hongwei Zhang (B5 associated 2) and Joshua Adjah (B5-3).

Sebastian Rausch
Image Credit: Institut für Immunologie

Freie Universität Berlin

Department of Veterinary Medicine

Institute of Immunology

Research interest:

  • Infection Biology
  • Immunology

Liublin W, Rausch S, Leben R, Liebeskind J, Hauser AE, Hartmann S, Niesner RA. (2023).
NAD(P)H Fluorescence Lifetime Imaging for the Metabolic Analysis of the Murine Intestine and Parasites During Nematode Infection.
J Vis Exp Sep 1;(199). doi: 10.3791/64982.

Schlosser-Brandenburg J, Midha A, Mugo RM, Ndombi EM, Gachara G, Njomo D, Rausch S, Hartmann S. (2023).
Infection with soil-transmitted helminths and their impact on coinfections.
Front Parasitol published May 24. doi: 10.3389/fpara.2023.1197956. Review

Elizalde-Velázquez LE, Yordanova IA, Liublin W, Adjah J, Leben R, Rausch S, Niesner R, Hartmann S. (2023).
Th2 and metabolic responses to nematodes are independent of prolonged host microbiota abrogation.
Parasite Immunol 45:e12957. doi: 10.1111/pim.12957.

Hamid B, Ebner F, Bechtold L, Kundik A, Rausch S, Hartmann S. (2022).
Ascaris suum excretory/secretory products differentially modulate porcine dendritic cell subsets.
Front Immunol 13:1012717. doi: 10.3389/fimmu.2022.1012717.

Liublin W, Rausch S, Leben R, Lindquist RL, Fiedler A, Liebeskind J, Beckers IE, Hauser AE, Hartmann S, Niesner RA. (2022).
NAD(P)H fluorescence lifetime imaging of live intestinal nematodes reveals metabolic crosstalk between parasite and host.
Sci Rep 12:7264. doi: 10.1038/s41598-022-10705-y.

Kapse B, Zhang H, Affinass N, Ebner F, Hartmann S, Rausch S. (2022).
Age-dependent rise in IFN-γ competence undermines effective type 2 responses to nematode infection.
Mucosal Immunol Jun 11. doi: 10.1038/s41385-022-00519-6.

Zhang H, Bednář L, Heitlinger E, Hartmann S, Rausch S. (2022).
Whip- and pinworm infections elicit contrasting effector and distinct regulatory responses in wild house mice.
Int J Parasitol 52:519-24. doi: 10.1016/j.ijpara.2022.03.006.

Hamid B, Schlosser-Brandenburg J, Bechtold L, Ebner F, Rausch S, Hartmann S. (2021).
Early Immune Initiation by Porcine Cells following Toxoplasma gondii Infection versus TLR Ligation.
Microorganisms 9:1828. doi: 10.3390/microorganisms9091828.

Midha A, Ebner F, Schlosser-Brandenburg J, Rausch S, Hartmann S. (2021).
Trilateral relationship: Ascaris, microbiota, and host cells.
Trends Parasitol 37:251-62. doi: 10.1016/j.pt.2020.09.002.

Yordanova IA, Lamatsch M, Kühl AA, Hartmann S, Rausch S. (2021)
Eosinophils are dispensable for the regulation of IgA and Th17 responses in Giardia muris infection.
Parasite Immunol 43:e12791. doi: 10.1111/pim.12791.

Yordanova IA, Cortés A, Klotz C, Kühl AA, Heimesaat MM, Cantacessi C, Hartmann S, Rausch S. (2019).
RORγt+ Treg to Th17 ratios correlate with susceptibility to Giardia infection.
Sci Rep 9:20328. doi: 10.1038/s41598-019-56416-9.

Yordanova I*, Zakovic S*, Rausch S, CostaG, Levashina E, Hartmann S. (2018).
Micromanaging immunity in the murine hosts versus mosquito vectors: microbiota-dependent immune responses to intestinal parasites.
Front Cell Infect Microbiol 8:308. doi: 10.3389/fcimb.2018.00308. *equal contribution

Rausch S, Midha A, Kuhring M, Affinass N, Radonic A, Kühl AA, Bleich A, Renard BY, Hartmann S. (2018).
Parasitic nematodes exert antimicrobial activity and benefit from microbiota-driven support for host immune regulation. Front Immunol 9:2282. doi: 10.3389/fimmu.2018.02282.

Affinass N, Zhang H, Löhning M, Hartmann S, Rausch S. (2018).
Manipulation of the balance between Th2 and Th2/1 hybrid cells effects parasite nematode fitness.
Eur J Immunol 48:1958-64. doi: 10.1002/eji.201847639.

Ahmed N, French T, Rausch S, Kühl AA, Hemminger K, Dunay I, Steinfelder S, Hartmann S. (2017).
Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response.
Front Cell Infect Microbiol 7:341. doi: 10.3389/fcimb.2017.00341.

Bock,C, Babu S, Breloer M, Rajamanickam A, Boothra Y, Brunn ML, Kühl AA, Merle R, Löhning M, Hartmann S, Rausch S. (2017).
Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells
Front Cell Infect Microbiol 7:261. doi: 10.3389/fcimb.2017.00261.

Maaz D, Rausch S, Richter D, Krücken J, Kühl AA, Demeler J, Blümke J, Matuschka FR, von Samson-Himmelstjerna G, Hartmann S. (2016).
Susceptibility to ticks and Lyme disease spirochetes is not affected in mice co-infected with nematodes.
Infect Immun 84:1274–86. doi: 10.1128/IAI.01309-15.

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