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Prof. Susanne Hartmann

Project B4: Effect of a previous protozoan infection with Toxoplasma co-infection prevents Th2 differentiation and leads to a helminth-specific Th1 response: PhD students Norus Ahmed (B4-1), Benjamin Hamid (B4-2), Ankur Midha (associated 1) and Luis Elizalde (B4-3).

Participating researcher in project B5: Differential instruction of Th2 cells during nematode and tick infections

Susanne Hartmann
Image Credit: Susanne Hartmann

Freie Universität Berlin

Department of Veterinary Medicine

Institute of Immunology

Speaker of the RTG 2046

Research interest:

  • Immunomodulation by parasites

Oser L, Midha A, Schlosser-Brandenburg J, Rausch S, Mugo RM, Kundik A, Elizalde-Velázquez LE, Adjah J, Musimbi ZD, Klopfleisch R, Helm CS, von Samson-Himmelstjerna G, Hartmann S, Ebner F. (2024).
Ascaris suum infection in juvenile pigs elicits a local Th2 response in a setting of ongoing Th1 expansion.
Front Immunol 15:1396446. doi: 10.3389/fimmu.2024.1396446.

Liublin W, Rausch S, Leben R, Liebeskind J, Hauser AE, Hartmann S, Niesner RA. (2023).
NAD(P)H Fluorescence Lifetime Imaging for the Metabolic Analysis of the Murine Intestine and Parasites During Nematode Infection.
J Vis Exp Sep 1;(199). doi: 10.3791/64982.

Kundik A, Musimbi ZD, Krücken J, Hildebrandt T, Kornilov O, Hartmann S, Ebner F. (2023).
Quantifying metabolic activity of Ascaris suum L3 using resazurin reduction.
Parasit Vectors 16:243. doi: 10.1186/s13071-023-05871-5.

Schlosser-Brandenburg J, Midha A, Mugo RM, Ndombi EM, Gachara G, Njomo D, Rausch S, Hartmann S. (2023).
Infection with soil-transmitted helminths and their impact on coinfections.
Front Parasitol published May 24. doi: 10.3389/fpara.2023.1197956. Review

Yordanova IA, Elizalde-Velázquez LE, Hartmann S. (2023).
Immunization with excretory-secretory molecules of intestinal nematodes induces antigen-specific protective memory Th2 cell responses.
Eur J Immunol Feb 13:e2250237. doi: 10.1002/eji.202250237.

Elizalde-Velázquez LE, Yordanova IA, Liublin W, Adjah J, Leben R, Rausch S, Niesner R, Hartmann S. (2023).
Th2 and metabolic responses to nematodes are independent of prolonged host microbiota abrogation.
Parasite Immunol 45:e12957. doi: 10.1111/pim.12957.

Hamid B, Ebner F, Bechtold L, Kundik A, Rausch S, Hartmann S. (2022).
Ascaris suum excretory/secretory products differentially modulate porcine dendritic cell subsets.
Front Immunol 13:1012717. doi: 10.3389/fimmu.2022.1012717.

Liublin W, Rausch S, Leben R, Lindquist RL, Fiedler A, Liebeskind J, Beckers IE, Hauser AE, Hartmann S, Niesner RA. (2022).
NAD(P)H fluorescence lifetime imaging of live intestinal nematodes reveals metabolic crosstalk between parasite and host.
Sci Rep 12:7264. doi: 10.1038/s41598-022-10705-y.

Kapse B, Zhang H, Affinass N, Ebner F, Hartmann S, Rausch S. (2022).
Age-dependent rise in IFN-γ competence undermines effective type 2 responses to nematode infection.
Mucosal Immunol Jun 11. doi: 10.1038/s41385-022-00519-6.

Zhang H, Bednář L, Heitlinger E, Hartmann S, Rausch S. (2022).
Whip- and pinworm infections elicit contrasting effector and distinct regulatory responses in wild house mice.
Int J Parasitol 52:519-24. doi: 10.1016/j.ijpara.2022.03.006.

Schlosser-Brandenburg J, Ebner F, Klopfleisch R, Kühl AA, Zentek J, Pieper R, Hartmann S. (2021).
Influence of Nutrition and Maternal Bonding on Postnatal Lung Development in the Newborn Pig.
Front Immunol 12:734153. doi: 10.3389/fimmu.2021.734153.

Hamid B, Schlosser-Brandenburg J, Bechtold L, Ebner F, Rausch S, Hartmann S. (2021).
Early Immune Initiation by Porcine Cells following Toxoplasma gondii Infection versus TLR Ligation.
Microorganisms 9:1828. doi: 10.3390/microorganisms9091828.

Midha A,Goyette-Desjardins G, Goerdeler F, Moscovitz O, Seeberger PH, Tedin K, Bertzbach LD, Lepenies B, Hartmann S. (2021).
Lectin-Mediated Bacterial Modulation by the Intestinal Nematode Ascaris suum.
Int J Mol Sci 22:8739. doi: 10.3390/ijms22168739.

Yordanova IA, Ebner F, Schulz AR, Steinfelder S, Rosche B, Bolze A, Paul F, Mei HE, Hartmann S. (2021).
The Worm-Specific Immune Response in Multiple Sclerosis Patients Receiving Controlled Trichuris suis Ova Immunotherapy.
Life (Basel) 11:101. doi: 10.3390/life11020101.

Midha A, Ebner F, Schlosser-Brandenburg J, Rausch S, Hartmann S. (2021).
Trilateral relationship: Ascaris, microbiota, and host cells.
Trends Parasitol 37:251-62. doi: 10.1016/j.pt.2020.09.002.

Yordanova IA, Lamatsch M, Kühl AA, Hartmann S, Rausch S. (2021)
Eosinophils are dispensable for the regulation of IgA and Th17 responses in Giardia muris infection.
Parasite Immunol 43:e12791. doi: 10.1111/pim.12791.

Ebner F, Morrison E, Bertazzon M, Midha AHartmann S, Freund C, Álvaro-Benito M. (2020).
CD4+ Th immunogenicity of the Ascaris spp. secreted products.
NPJ Vaccines 5:25. doi: 10.1038/s41541-020-0171-z.

Yordanova IA,  Cortés A, Klotz C, Kühl AA, Heimesaat MM, Cantacessi C, Hartmann S, Rausch S. (2019).
RORγt+ Treg to Th17 ratios correlate with susceptibility to Giardia infection.
Sci Rep 9: 20328. doi: 10.1038/s41598-019-56416-9.

French T, Düsedau HP, Steffen J, Biswas A, Ahmed N, Hartmann S, Schüler T, Schott BH, Dunay IR. (2019).
Neuronal impairment following chronic Toxoplasma gondii infection is aggravated by intestinal nematode challenge in an IFN-γ-dependent manner.
J Neuroinflammation 16:159. doi: 10.1186/s12974-019-1539-8.

Ahmed N, Heitlinger E, Affinass N, Kühl AA, Xenophontos N, Jarquin VH, Jost J, Steinfelder S, Hartmann S. (2019).
A novel non-invasive method to detect RELM beta transcript in gut barrier related changes during a gastrointestinal nematode infection.
Front Immunol 10:445. doi: 10.3389/fimmu.2019.00445.

Delgado Betancourt E, Hamid B, Fabian BT, Klotz C, Hartmann S, Seeber F. (2019).
From Entry to Early Dissemination-Toxoplasma gondii's Initial Encounter With Its Host.
Front Cell Infect Microbiol 9:46. doi: 10.3389/fcimb.2019.00046.

Rausch S, Midha A, Kuhring M, Affinass N, Radonic A, Kühl AA, Bleich A, Renard BY, Hartmann S. (2018).
Parasitic nematodes exert antimicrobial activity and benefit from microbiota-driven support for host immune regulation.
Front Immunol 9:2282. doi: 10.3389/fimmu.2018.02282.

Affinass N, Zhang H, Löhning M, Hartmann S, Rausch S. (2018).
Manipulation of the balance between Th2 and Th2/1 hybrid cells effects parasite nematode fitness.
Eur J Immunol 48:1958-64. doi: 10.1002/eji.201847639.

Yordanova I*, Zakovic S*, Rausch S, CostaG, Levashina E, Hartmann S. (2018).
Micromanaging immunity in the murine hosts versus mosquito vectors: microbiota-dependent immune responses to intestinal parasites.
Front Cell Infect Microbiol 8:308. doi: 10.3389/fcimb.2018.0030. *equal contribution

Ebner F, Kuhring M, Radonić A, Midha A, Renard B, Hartmann S. (2018).
Silent witness: Dual-species transcriptomics reveals epithelial immunological quiescence to helminth larval encounter and fostered larval development.
Front Immunol 9:1868. doi: 10.3389/fimmu.2018.01868.

Midha A, Janek K, Niewienda A, Henklein P, Guenther S, Serra DO, Schlosser J, Hengge R, Hartmann S. (2018).
The intestinal roundworm Ascaris suum releases antimicrobial factors which interfere with bacterial growth and biofilm formation.
Front Cell Infect Microbiol 8:271. doi: 10.3389/fcimb.2018.00271.

Midha A, Janek K, Niewienda A, Henklein P, Guenther S, Serra DO, Schlosser J, Hengge R, Hartmann S. (2018).
Corrigendum: The Intestinal Roundworm Ascaris suum Releases Antimicrobial Factors Which Interfere With Bacterial Growth and Biofilm Formation.
Front Cell Infect Microbiol 8:367. doi: 10.3389/fcimb.2018.00367.

Aebischer T, Matuschewski K, Hartmann S. (2018).
Editorial: Parasite Infections: From Experimental Models to Natural Systems.
Front Cell Infect Microbiol 8: 1–3. doi: 10.3389/fcimb.2018.00012.

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Volkers SM, Thada S, Dietert K, Bauer L, Schäfer A, Helbig ET, Opitz B, Kurth F, Sur S, Dittrich N, Gaddam S, Conrad ML, Benn CS, Blohm U, Gruber AD, Hutloff A, Hartmann S, Boekschoten MV, Müller M, Jungersen G, Schumann RR, Suttorp N, Sander LE. (2018).
Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.
Nat Immunol 19: 386–96. doi:10.1038/s41590-018-0068-4.

Ahmed N, French T, Rausch S, Kühl A, Hemminger K, Dunay I, Steinfelder S, Hartmann S. (2017).
Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response.
Front Cell Infect Microbiol 7:1–12. doi: 10.3389/fcimb.2017.00341.

Bock C, Babu S, Breloer M, Rajamanickam A, Boothra Y, Brunn ML, Kühl AA, Merle R, Löhning M, Hartmann S, Rausch S. (2017).
Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells.
Front Cell Infect Microbiol 7: 1–15. doi: 10.3389/fcimb.2017.00261.

Kofer J, Hofer H, Hartmann S. (2017).
Next-Generation Parasitologists: Structured Training Programs Meet Educational Challenges.
Trends Parasitol 33:423–5. doi: 10.1016/j.pt.2017.03.008.

Midha A, Schlosser J, Hartmann S. (2017).
Reciprocal Interactions between Nematodes and Their Microbial Environments.
Front Cell Infect Microbiol 7:144. doi: 10.3389/fcimb.2017.00144.

Maaz D, Rausch S, Richter D, Krücken J, Kühl AA, Demeler J, Blümke J, Matuschka FR, von Samson-Himmelstjerna G, Hartmann S. (2016).
Susceptibility to ticks and Lyme disease spirochetes is not affected in mice co-infected with nematodes.
Infect Immun 84:1274–86. doi: 10.1128/IAI.01309-15.

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