Member since: April 2021

Research interest

Protozoan parasites, Glycobiology, Antibody therapy, Nanobodies

Title of PhD project
Functionalization of single-chain antibodies for the treatment of severe parasitic diseases

Supervisor
Prof. Dr. Peter H. Seeberger and Dr. Oren Moscovitz

Lühle J, Krost S, Goerdeler F, Valentí A, Shanin E, Seitz C, Seeberger PH, Moscovitz O. (2025).
Bifunctional Cysteine-Engineered CAR‑T Cells Enable Thiol-Mediated Targeting to Overcome Antigen Escape in B Cell Lymphoma.
ACS Cent Sci 11:1852-1861. doi: 10.1021/acscentsci.5c00816.

Goerdeler F, Reuber EE, Lühle J, Leichnitz S, Freitag A, Nedielkov R, Groza R, Ewers H, Möller HM, Seeberger PH, Moscovitz O. (2023).
Thiol-Mediated Uptake of a Cysteine-Containing Nanobody for Anticancer Drug Delivery.
ACS Cent Sci 9:1111-8. doi: 10.1021/acscentsci.3c00177.

Khilji SK, Op 't Hoog C, Warschkau D, Lühle J, Goerdeler F, Freitag A, Seeberger PH, Moscovitz O. (2023).
Smaller size packs a stronger punch - Recent advances in small antibody fragments targeting tumour-associated carbohydrate antigens.
Theranostics 13:3041-3063. doi: 10.7150/thno.80901.

Khilji SK*, Goerdeler F*, Frensemeier K, Warschkau D, Lühle J, Fandi Z, Schirmeister F, Chen ZA, Turak O, Mallagaray A, Boerno S, Timmermann B, Rappsilber J, Seeberger PH, Moscovitz O. (2022).
Generation of glycan-specific nanobodies.
Cell Chem Biol Jun 6:S2451-9456(22)00199-4. doi: 10.1016/j.chembiol.2022.05.007.*equal contribution

Ben Ami Pilo H*, Khilji SK*, Lühle J*, Biskup K, Gal BL, Rosenhek Goldian I, Alfandari D, Revach OY, Kiper E, Morandi MI, Rotlopf R, Porat Z, Blanchard V, Seeberger PH, Regev-Rudzki N, Moscovitz O. (2022).
Sialylated N-glycans mediate monocyte uptake of extracellular vesicles secreted from Plasmodium falciparum-infected red blood cells.
J Extracellular Biol 1:e33. doi: 10.1002/jex2.33. *equal contribution