Pathogen stage conversion is a hallmark of parasites in general and permits unprecedented vaccine strategies. In the case of malaria, experimental immunizations with arrested liver stages have proven safe and efficacious against challenge infections in mice, primates, and humans. However, the molecular tracks of immune recognition and the immune effector mechanisms against Plasmodium pre-erythrocytic stages remain largely unsolved. In order to gain a better immunological understanding of protective immune responses as opposed to parasite recognition, transgenic parasite lines will be used to analyse protein export during liver stage infection and it’s impact on the immune response to Plasmodium.
We are looking for a highly motivated student with a background in biology and some lab work experience. Applicants should be open to learn how to dissect mosquitos and prepare cells from organs. The possibility to perform mouse experiments (animal license) would be highly appreciated. In addition, they should be flexible time wise to help during larger immunological experiments.