Arbeitsgruppe Prof. Kohn

Research

 

Research Group Prof. Kohn

 

Areas of Scientific Interest

 

  • Infectious Diseases in the dog and cat (vector-borne diseases, canine and feline, leptospirosis, feline hemoplasmosis, Giardia spp. infection in small animals, canine Angiostrongylus infection)

  • Antibiotic Stewardship (infections of the urinary tract)

  • Multiresistant bacteria and nosocomial infection

  • Clinical immunology: Immune-mediated diseases (immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, immune-mediated polyarthritis), new treatment options

  • Transfusion medicine in the dog and cat (blood typing and compatibility testing, indications, side effects, safety issues, etc.)

  • Acute phase proteins in the dog and cat

  • Nanocarriers in feline hyperthyroidism

  • Canine chronic enteropathies (epidemiological aspects, diagnosis, biomarkers, etc.)

  • Renal disease and biomarkers

 

Cooperations

 

Faculty of Veterinary Medicine, FU Berlin:

Institute for Immunology, Biochemistry, Animal Nutrition, Epidemiology and Statistics, Animal Hygiene, Microbiology, Parasitology, Animal Pathology, Anatomy, Animal Physiology

 

National and International Universities:

Rudolf-Virchow Klinikum, Charite University Medicine, Berlin

Institute for Chemistry and Biochemistry, FU Berlin

Small Animal Clinic, Tierärztliche Hochschule Hannover

Nutrition Physiology, Universität Potsdam

Institute for Animal Hygiene, University of Leipzig

Gastrointestinal Laboratory, Texas AM University

Hebrew University of Jerusalem

Pathobiology, University of Bristol

Small Animal Clinic, University of Bristol

Parasitology, LM-University Munich / University of Zurich

School of Veterinary Medicine, University of Pennsylvania

 

Federal Research Institutes:

Federal Institute for Risk Assessment, Berlin

Federal Institute for Materials Research and Testing (BAM), Berlin

Epidemiology, Robert-Koch Institute, Berlin

Parasitology, Robert-Koch Institute, Berlin

German Red Cross Blood Service, Springe

 

Numerous Cooperations with Industry / Private laboratories

Important Publications (last 5 years)

Chirek, A.; Silaghi, C.; Pfister, K.; Kohn, B. Vorkommen von Anaplasma phagocytophilum bei Blutspenderhunden in canine blood donors in Berlin/Brandenburg (2006-2012): retrospektive Auswertung klinischer Daten und Bedeutung für die Transfusionsmedizin. Berl Münch Tierärztl Wochenschr DOI 10.2376/0005-9366-17005 [Epub ahead of print]

Chirek, A.; Kohn, B. Granulocytic anaplasmosis in 63 dogs: clinical signs, laboratory results, therapy and course of disease. J Small Anim Pract (accepted)

Hourani, L.; Weingart, C.; Kohn, B.
Alloimmunisation in transfused patients: serial cross-matching in a population of hospitalised cats.
J Feline Med Surg. 2017 Jan
doi: 10.1177/1098612X16688574. [Epub ahead of print]

Knöpfler, S.; Mayer-Scholl, A.; Luge, E.; Klopfleisch, R.; Gruber, A.D.; Nöckler, K.;
Kohn, B.
Evaluation of clinical, laboratory, imaging findings and outcome in 99 dogs with leptospirosis.
J Small Anim Pract.  2017, 58(10): 582-588

Lizer, J.; Grahlmann, M.; Hapke, H.; Velineni, S.; Lin, D.;
Kohn, B.
Evaluation of a rapid IgM detection test for diagnosis of acute leptospirosis in dogs.
Vet Rec. 2017. 180(21):517

Merten, N.; Weingart, C. ; Kohn, B.

Primäre Erythrozytose bei sechs Katzen

Berl Münch Tierärztl Wochenschr 2017

doi 10.2376/0005-9366-16040

Volkmann, M.; Steiner, J.M.; Fosgate, G.T.;, Zentek, J.; Hartmann, S.; Kohn, B.
Chronic Diarrhea in Dogs - Retrospective Study in 136 Cases.
J Vet Intern Med. 2017;31(4):1043-1055.

Paßlack, N.; Kohn, B.; Doherr, M.G.; Zentek, J.
Impact of Dietary Protein Concentration and Quality on Immune Function of Cats.
PLoS One. 2017 Jan 10;12(1):e0169822.

Stiller, J. ; Jasensky A.-K. ; Hennies, M.; Einspanier, R.; Kohn, B.
Validation of an enzyme-linked immunosorbent assay for measurement of feline haptoglobin.
J Vet Diagn Invest. 2016 Mar 9. [Epub ahead of print]; pii: 1040638716634397.

Brenten, T.; Morris, P.J.; Salt, C.; Raila, J.; Kohn, B.; Schweigert, F.J.; Zentek, J.

Age-associated and breed-associated variations in haematological and biochemical variables in young labrador retriever and miniature schnauzer dogs.

Vet Rec Open. 2016 May 16;3(1)

 

HeilmannR.M.; Volkmann, M.; Otoni, C.C.; Grützner, M.; Kohn, B.; Jergens, A.E.; SteinerJ.M.

Fecal S100A12 concentration predicts a lack of response to treatment in dogs with chronic enteropathies.

The Veterinary Journal. 2016, doi: 10.1016/j.tvjl.2016.03.001

 

Kohn, B.; Bal, G.; Chirek, A.; Rehbein, S.; Salama, A.

Treatment of 5 dogs with immune-mediated thrombocytopenia using Romiplostim

BMC Veterinary Research. 2016: 12(1):290

 

Klopfleisch, R.; Kohn, B.; Gruber, A.D.

Mechanisms of tumour resistance against chemotherapeutic agents in veterinary oncology

Vet J. 2016; 207:63-72

 

Liesner, J.M.; Krücken, J.; Schaper, R.; Pachnicke, S.; Kohn, B.; Müller, E.; Schulze, C.; von Samson-Himmelstjerna, G.

Vector-borne pathogens in dogs and red foxes from the federal state of Brandenburg, Germany.

Vet Parasitol. 2016; 224:44-51.

 

Riedel J.; Badewien-Rentzsch B.; Kohn B.; Hoeke L.; Einspanier R.

Characterization of key genes of the renin-angiotensin system in mature feline adipocytes and during in vitro adipogenesis.

J Anim Physiol Anim Nutr (Berl). Dez 100(6): 1139-1148

Schuller, S.; Callanan, J.J.; Worrall, S.; Francey, T.; Schweighauser, A.; Kohn, B.; Klopfleisch, R.; Posthaus, H.;  Nally, J.E.
Immunohistochemical detection of IgM and IgG in lung tissue of dogs with leptospiral pulmonary haemorrhage syndrome (LPHS).
Comp Immunol Microbiol Infect Dis. 2015 Jun; 40:47-53

Wardrop, K.J.; Birkenheuer, A.; Blais, M.C.; Callan, M.B.; Kohn, B.; Lappin, M.R.; Sykes, J.
Update on Canine and Feline Blood Donor Screening for Blood-Borne Pathogens.
J Vet Intern Med. 2016; 30(1):15-35.

Weingart, C.; Tasker, S.; Kohn, B.  

Infection with haemoplasma species in 22 cats with anaemia.

J Feline Med Surg. 2016, 18(2):129-136.

 

Lazzerini, K.; Tipold, A.; Kornberg, M.; Silaghi, C.; Mietze, A.; Lübke-Becker, A.; Balling, A.; Pfeffer, M.; Wieler, L.H.; Pfister, K.; Kohn, B. (2015)

Testing for Vector-Transmitted Microorganisms in dogs with Meningitis and Meningoencephalitis of unknown aetiology. J Vet Med Res 2(1): 1014.

 

Jasensky, A.K.; Klenner, S.; Einspanier, R.; Kohn, B. (2015)

Evaluation of three different point-of-care tests for quantitative measurement of canine C-reactive protein (cCRP). Vet Clin Pathol. 2015 May 11. doi: 10.1111/vcp.12264.

 

Sainz, A.; Roura, X.; Guadalupe, M.; Estrada-Peña, A.; Kohn, B.; Harrus, S.; Solano-Gallego, L. (2015)

Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe.

Parasit Vectors.  Feb 4;8(1):75

 

Schaufler, K.; Bethe, A.; Lübke-Becker, A.; Ewers, C.; Kohn B.;  Wieler, L.H.; Guenther, S. (2015)

Putative connection between zoonotic multiresistant extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in dog feces from a veterinary campus and clinical isolates from dogs. http://www.infectionecologyandepidemiology.net/index.php/iee/article/view/25334

 

Schuller, S.; Francey, T.; Hartmann, K.; Hugonnard, M.; Kohn, B.; Nally, J.E.; Sykes, J. (2015)

European consensus statement on leptospirosis in dogs and cats.

J Small Anim Pract. Mar;56(3):159-79.

Schuller, S.; Callanan, J.J.; Worrall, S.; Francey, T.; Schweighauser, A.; Kohn, B.; Klopfleisch, R.; Posthaus, H.;  Nally, J.E. (2015)
Immunohistochemical detection of IgM and IgG in lung tissue of dogs with leptospiral pulmonary haemorrhage syndrome (LPHS). Comp Immunol Microbiol Infect Dis. 2015 Apr 30. pii: S0147-9571(15)00027-2.

Merten, N.; Weingart, C.; Kohn, B. (2015)

Ursachen, Diagnostik und Verlauf bei 194 Katzen mit Anämie

Berl. Münch Tierärztl Wschr 128 (9/10), 384-393

 

Wächter, M.; Pfeffer, M.; Schulz, N.; Balling, A.; Chirek, A.; Bach, J.P.; Moritz, A.; Kohn, B.; Pachnicke, S.; Silaghi, C.  (2015)

Seroprevalence of Spotted Fever Group Rickettsiae in Dogs in Germany.

Vector Borne Zoonotic Dis. Mar;15(3):191-194.

 

Volkmann, M.; Kohn, B. (2015)

Durchfall und Erbrechen beim Hund.

CVE 2015 · 1 (6): 1–20 · © Veterinär Verlag 2015

 

Merten, N.; Weingart, C.; Kohn, B. (2015)

Ursachen, Diagnostik und Verlauf bei 194 Katzen mit Anämie

Berl. Münch Tierärztl Wschr 128 (9/10), 384-393

 

Wächter, M.; Wölfel, S.; Pfeffer, M.; Dobler, G.; Kohn, B.; Moritz, A.; Pachnicke, S.; Silaghi, C. (2015)

Serological differentiation of antibodies against Rickettsia helvetica, R. raoultii, R. slovaca, R. monacensis and R. felis in dogs from Germany by a micro-immunofluorescent antibody test.

Parasit Vectors. Dec;8(1):745.

 

Beck, S.; Schreiber, C.; Schein, E.; Krücken, J.; Baldermann, C.; Pachnicke, S.; von Samson-Himmelstjerna, G.; Kohn, B. (2014)

Tick infestation and prophylaxis of dogs in northeastern Germany: a prospective study.

Ticks Tick Borne Dis. 5(3):336-42.

Brenten, T.; Morris, P.J.; Salt, C.; Raila, J.; Kohn, B.; Brunnberg, L.; Schweigert, F.J.; Zentek J. (2014)
Energy intake, growth rate and body composition of young Labrador Retrievers and Miniature Schnauzers fed different dietary levels of vitamin A. Br J Nutr. 25:1-8.

Hourani, L.; Weingart, C.; Kohn, B. (2014)

Evaluation of a novel feline AB blood typing device.

J Feline Med Surg., 16: 826-831

 

Jasensky, A.K.; Bondzio, A.; Murugaiyan, J.; Siebert, U.; Roesler, U.; Kohn, B.; Einspanier, R. (2014)

Characterization of the native C-reactive protein (cCRP) and the corresponding liver mRNA in dogs. Biochem Biophys Res Commun. 26;452(3):462-7.

 

Raila, J.; Schweigert, F.J.; Kohn, B. (2014)

Relationship between urinary Tamm-Horsfall protein excretion and renal function in dogs with naturally occurring renal disease.

Vet Clin Pathol.; 43(2):261-5.

 

Schreiber, C.; Krücken, J.; Beck, S.; Maaz, D.; Pachnicke, S.; Krieger, K.; Gross, M.; Kohn, B., von Samson-Himmelstjerna, G. (2014)

Pathogens in ticks collected from dogs in Berlin/Brandenburg, Germany. Parasit Vectors. Dec 2;7(1):535.

 

Volkmann, M.; Hepworth, MR.; Ebner, F.; Rausch, S.; Kohn, B. , Hartmann, S. (2014)

Frequencies of regulatory T cells in peripheral blood of dogs with primary immune-mediated thrombocytopenia and chronic enteropathy: a pilot study.

Vet J. 202(3):630-3.

 

Beck, S.; Schein, E.; Baldermann, C.; Samson-Himmelstjerna, G.v.; Kohn, B. (2013)

Zeckeninfestation und Zeckenprophylaxe bei Hunden im Raum Berlin/Brandenburg-Ergebnisse einer Fragebogenstudie. Berl Münchn Tierärztl Wschr 126, 1-2, 69-76

 

Da Costa, A.; Kohn, B.; Gruber, A.D.; Klopfleisch, R. (2013)

Multiple RT-PCR markers for the detection of circulating tumour cells of metastatic canine mammary tumours. Vet J. 2013 Apr;196(1):34-9

 

Mayer-Scholl, A.; Luge, E.; Draeger, A.; Nöckler, K.; Kohn, B.(2013)

Distribution of Leptospira serogroups in dogs from Berlin, Germany. Vector Borne Zoonotic Dis. Mar;13(3):200-2.

 

Krücken, J.; Schreiber, C.; Maaz, D.; Kohn, M.; Demeler, J.; Beck, S.; Schein, E.; Olias, P.; Richter, D.; Matuschka, F.R.; Pachnicke, S.; Krieger, K.; Kohn, B.; von Samson-Himmelstjerna, G. (2013)

A novel high-resolution-melt PCR discriminates Anaplasma phagocytophilum and Candidatus Neoehrlichia mikurensis. J Clin Microbiol. 2013 Jun;51(6):1958-61.

 

Sassnau, R.; Kohn, M.; Demeler, J; Kohn, B.; Müller, E.; Krücken, J.; von Samson-Himmelstjerna, G. (2013)

Is Dirofilaria repens endemic in the Havelland District in Brandenburg, Germany ?

Vector Borne Zoonotic Dis. Dec;13(12):888-91.

 

Volkmann, M.; Wirtherle, N.; Beddies, G.; Kohn, B. (2013)

Efficacy of AST-120 in dogs with chronic idiopathic enteropathies. J Vet Intern Med. 2013 Oct 15. doi: 10.1111/jvim.12212.

 

Weingart, C.; Kershaw, O.; Gruber, A.D.; Kohn, B. (2013)

Störungen des Wasserhaushaltes bei zwei Hunden und einer Katze mit ZNS-Erkrankungen.

Schweiz Arch Tierheilkd. 155: 463-469

 

Bauer, C.; Brahm, R.; Daugschies, A.; Kietzmann, M.; Kohn, B.; Moritz, A.; Müller R; Schnieder, T.; Wendland, B. (2012)

Bekämpfung von parasitischen Milben bei Hunden und Katzen. Kleintierpraxis 57 (6), 335 - 340

 

Baneth, G.; Bourdeau, P.; Bourdoiseau, G.; Bowman, D.; Breitschwerdt, E.; Capelli, G.; Cardoso, L.; Dantas-Torres, F.; Day, M.; Dedet, J.P.; Dobler, G.; Ferrer, L.; Irwin, P.; Kempf, V. ; Kohn, B.; Lappin, M.; Little, S.; Maggi, R.; Guadalupe Miró, G.; Naucke, T.; Oliva, G.; Otranto, D. ; Penzhorn, B.; Pfeffer, M.;  Roura, X.; Sainz, A.; Shaw, S.; Shin, S.; Solano-Gallego, L.; Straubinger, R.; Traub, R.; Trees, A.; Truyen, U.; Demonceau, T.; Fitzgerald, R.; Gatti, D.; Hostetler, J.; Kilmer, B.; Krieger, K.; Mencke, N.; Mendão, C.;  Mottier, L.; Pachnicke, S.; Rees, B.; Siebert, S.; Stanneck, D.;  Montserrat Tarancón Mingote, M.; von Simson, C.; Weston, S. (2012)

Vector-Borne Diseases – constant challenge for practicing veterinarians: recommendations from the CVBD World Forum. Parasites and Vectors Mar 20;5(1):55

 

Bäcker, C.; Kohn, B. ; Lotz, F. , Rühe, B. ; Brunnberg, L. ; Kellermeier, C. (2012)

„Dental Home Care“. Resultate einer Studie mit 50 Hunden zum Thema. Vet Journal, 65. Jahrgang, 16 - 24

 

Beck, S. ; Schein, E. ; Baldermann, C.; Samson-Himmelstjerna, G.v. ; Kohn, B. (2013)

Zeckeninfestation und Zeckenprophylaxe bei Hunden im Raum Berlin/Brandenburg-Ergebnisse einer Fragebogenstudie. Berl Münchn Tierärztl Wschr 126, 1-2, 69-76

 

Da Costa, A.; Kohn, B.; Gruber, A.D.; Klopfleisch, R. (2012)

Multiple RT-PCR markers for the detection of circulating tumour cells of metastatic canine mammary tumours.

Vet J 2012 Oct 1. pii: S1090-0233(12)00370-X. doi: 10.1016/j.tvjl.2012.08.021. [Epub ahead of print]

 

Da Costa, A.; Lenze, D.; Hummel, M.; Kohn, B.; Gruber, A.D.; Klopfleisch, R. (2012)

Identification of Six Potential Markers for the Detection of Circulating Canine Mammary Tumour Cells in the Peripheral Blood Identified by Microarray Analysis.J Comp Pathol., Vol. 146, 143-151

 

Graf, C.; Raila, J.; Schweigert, F.J.; Kohn, B. (2012)

Effect of leukoreduction treatment on the vascular endothelial growth factor concentration in stored canine blood transfusion products. Am J Vet Res. 73(12):2001-6

 

Kohn, B.; Classe, G., Weingart, C. (2012)

Clinical evaluation of the QuickVet®/RapidVet® canine dog erythrocyte antigen 1.1 blood-typing test. J Vet Diagnost Invest 24(3): 539-545

 

Kohn, B. ; Weingart, C.; Mayer-Scholl A., Nöckler K. (2012)

Leptospirose beim Hund – aktuelle Aspekte zu Klinik, Diagnose, Therapie und Prophylaxe.

Kleintierpraxis 57, 461-474

 

Morris, P.J.; Salt, C., Raila, J.; Brenten, T.; Kohn, B.; Schweigert, F.J. ; Zentek, J. (2012)

Safety evaluation of vitamin A in growing dogs. Br J Nutr. Feb 28:1-10.

 

Morgenthal, D.; Hamel, D. ; Arndt, G.; Silaghi, C.; Pfister, K. ; Kempf, V. A.J. ;  Kohn, B. (2012)

Prävalenz von hämotrophen Mycoplasma spp., Bartonella spp. und Anaplasma phagocytophilum bei Katzen im Raum Berlin/Brandenburg. Berliner und Münchner Tierärztliche Wochenschrift 125, 9/10, 418-427

 

Pohler, P.; Lehmann, J.; Veneruso, V.; Tomm, J.; V.; Lambrecht, B.; Kohn, B., Weingart, C. , Müller, T.H., Seltsam, A. (2012)

Evaluation of the tolerability and immunogenicity of ultraviolet C-irradiated autologous platelets in a dog model. Transfusion. 52(11):2414-26.

 

Walther, B. ; Lübke-Becker, A.; Brunnberg, L.; Kohn, B.; Wieler, L.H. (2012)

Einsatz von Antibiotika in der Kleintiermedizin: Quo vadis? Der Praktische Tierarzt, 92(12), 1047-1049

 

Walther, B.; Hermes, J.; Cuny, C.; Wieler, L.H.; Vincze, S.; Abou Elnaga, Y.; Stamm, I.; Kopp, P.A.; Kohn, B.; Witte, W.; Jansen, A.;  Conraths, F.J.; Semmler, T.;Eckmanns, T., Lübke-Becker, A. (2012)

Sharing More than Friendship — Nasal Colonization with Coagulase-Positive Staphylococci (CPS) and Co-Habitation Aspects of Dogs and Their Owners . PLoS One. 7(4):e35197

Walther, B.; Wieler, L.H.; Vincze, S.; Antão, E.M.; Brandenburg, A.; Stamm, I.; Kopp, P.A.; Kohn, B.; Semmler, T.; Lübke-Becker, A. (2012)

MRSA variant in companion animals. Emerg Infect Dis. 2012 Dec;18(12):2017-20. doi: 10.3201/eid1812.120238

 

Weingart, C.; Lotz, F.; Kohn, B. (2012)

Validation of the portable ketone meter Precision Xceed® in cats. Vet Clin Pathol Mar;41(1):114-8. doi: 10.1111/j.1939-165X.2011.00389.x. Epub 2012 Jan 17. (epub)

 

Weingart, C.; Lotz, F.; Kohn, B (2012)

Measurement of β-hydroxybutyrate in cats with nonketotic diabetes mellitus, diabetic

ketosis and diabetic ketoacidosis. J Vet Diagn Invest 24: 295-300

 

Weingart, C.; Kohn, B. (2012)

Pathophysiologie und diagnostische Bedeutung von Ketonkörpern bei Diabetes mellitus bei Hund und Katze. Kleintierpraxis 57: 156-166