Research in our group is centered around host:bacterial interactions, including probiotic bacteria as well as the facultative intracellular pathogen Salmonella Typhimurium and other Salmonella serovars. As one of the three major zoonotic infectious agents causing gastrointestinal infections worldwide, Salmonella remains a health problem in both developed and developing countries. To date, very little is known about the factors involved in host-adaptation or -restriction of Salmonella serovars. Furthermore, host-adapted serovars may persist in animal populations such as swine and poultry, but also cause life-threatening systemic infections in humans. Our research is focussed on host and bacterial factors involved in host adaptation and persistence of the zoonotic pathogen Salmonella in human, porcine and avian cell culture models of infection; interactions of intracellular Salmonella with host cell processes involved in supporting the growth of the pathogen in infected cells; and bacterial immunomodulation of host innate immune responses both in vitro and in vivo in swine infection models.