The understanding of the metabilic adaptability of high-yielding dairy cows in different reproduction and lactation states requires a detailed assessment of the different regulatory planes of metabolic processes. Our research is focused on the elucidation and targeted dietary manipulation of such processes.
By using integrative research strategies, studies are executed on cell models (primarily bovine adipocyte cultures) and the living animal. Apart from various molecular biology methods such as transcriptomics (quantitative RT-PCR, oligonucleotide microarrays) and analysis of protein expression (Western Blots), we also apply a portfolio of different functional tests to assess the metabolic processes. Our major goal is the identification of molecular targets with high relevance for 'metabolic health' in critical production periods and their manipulation by natural feed ingredients.