Publikationen AG Hartmann

  • Rausch, S., J. Held, A. Fischer, M. M. Heimesaat, A. A. Kühl, S. Bereswill, and S. Hartmann. 2013. Small intestinal nematode infection of mice is associated with increased enterobacterial loads alongside the intestinal tract. PLOS ONE, in press.

  • Peine, M., S. Rausch, C. Helmstetter, A. Fröhlich, A. N. Hegazy, A. A. Kühl, C. G. Grevelding, T. Höfer, S. Hartmann, and M. Loehning. 2013. Stable T-bet+GATA-3+ Th1/Th2 hybrid cells arise in vivo, can develop directly from naïve precursors, and limit immunopathologic inflammation. PLOS Biology, in press.

  • Hering, N.A.*, J.F. Richter* (*shared first authorship), A. Fromm, A. Wieser, S. Hartmann, D. Günzel, R. Bücker, M. Fromm, J.D. Schulzke° (°corresponding author), H. Troeger. 2013. TcpC protein from E. coli Nissle improves epithelial barrier function involving PKCζ and ERK1/2 signalling in HT-29/B6 cells. Mucosal Immunol., in press.
  • Daniłowicz-Luebert, E., S. Steinfelder, A. Kühl, G. Drozdenko, R. Lucius, M. Worm, E. Hamelmann, S. Hartmann. 2013. A nematode immunomodulator inhibits grass pollen-specific allergic responses by controlling excessive Th2 inflammation. Int.J. Parasitol., 43:201-210.
  • Hepworth M.R. and S. Hartmann. 2012. Worming our way closer to the clinic. IJPDDR 187-190.
  • Hepworth M.R., M. Maurer and S. Hartmann. 2012. Regulation of type 2 immunity to helminths by mast cells. Gut Microbes 3:5.
  • Hepworth M.R., E. Daniłowicz-Luebert, S. Rausch,  M. Metz, C. Klotz, M. Maurer and  S. Hartmann. 2012. Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines. PNAS, 109:6644-6649.
  • Greiff, V., H. Redestig, J. Lück, N. Bruni, A. Valai, S. Hartmann, S. Rausch, J. Schuchhardt and M. Or-Guil. 2012. A minimal model of peptide binding predicts ensemble properties of serum antibodies. BMC Genomics 13:79.
  • Stange, J., M. Hepworth, S. Rausch, L. Zajic, A.J. Kühl, C. Uyttenhove, J.C. Renauld, S. Hartmann, R. Lucius. 2012. IL-22 mediates host defense against an intestinal intracellular parasite in the absence of IFN-γ at the cost of Th17-driven immunopathology. J Immunol., 188(5):2410-8.
  • Klotz, C., T. Ziegler, A.S. Figureiedo, S. Rausch, M. Hepworth, C. Sers, P. Hammerstein, R. Lucius, S. Hartmann. 2011. A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages. PLoS Pathogens, 7:e1001248.
  • E. Danilowicz-Luebert, N.L. O’Regan, S. Steinfelder, S. Hartmann. 2011. Modulation of specific and allergy-related immune responses by helminths. J. Biomed. Biotechnol., Epub Dec 15.
  • Whelan R.A., S. S. Hartmann, S. Rausch. 2011. Nematode modulation of inflammatory bowel disesase. Protoplasma 2011.
  • Klotz, C., E. Danilowicz, T. Ziegler, S. Hartmann. 2011. Cystatins of parasitic organisms. Adv. Exp.Med. Biol., 712:208-221.
  • Rausch, S., J. Held, J, Stange, M. Lendner, M. Hepworth, C. Klotz, R. Lucius, T. Pogonka, S. Hartmann. 2010. A Matter of Timing: Impact of intestinal nematode infection on concurrent enteric protozoan infection. In press. Eur. J. Immunol., 40:2804-2815.
  • Sereda, M., S. Hartmann, D. Büttner, R. Volkmer, M. Hövestädt, N. Brattig, R. Lucius. 2010. Characterization of filarial tropomyosin with an invertebrate specific monoclonal antibody. Acta Tropica, 116:61-67.
  • Hepworth, M., E. Hamelmann, R. Lucius, S. Hartmann. 2010. Looking into the future of Trichuris suis therapy. J. Allergy Clin. Immunol., 124:767-768.
  • Rausch, S., J. Huehn, C. Loddenkemper, M. Hepworth, C. Klotz, T. Sparwasser, A. Hamann, R. Lucius,S. Hartmann. 2009. Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells. Eur. J. Immunol., 39:3066-3077.
  • Hartmann, S., C. Schnoeller, A. Dahten, A. Avagyan, S. Rausch, M. Lendner, C. Bocian, S. Pillai, R. Lucius, M. Worm, E. Hamelmann. 2009. Gastrointestinal nematode infection interferes with experimental allergic airway inflammation but not atopic dermatitis. Clinical & Experimental Allergy, 39:1585-1596.
  • Rzepecka, J., S. Rausch, C. Klotz, C. Schnöller, T. Kornprobst, J. Hagen, R. Ignatius, R. Lucius, S. Hartmann. 2009. Calreticulin from the intestinal nematode Heligmosomoides polygyrus is a Th2-skewing protein and interacts with murine scavenger receptor-A. Molecular Immunology, 46:1109-1119.
  • He, Y., A. MacDonald, Y. Yu, L. Cao, J. Li, R. Parhar, S. Heck, S. Hartmann, D. Golenbock, S. Jiang, S. Lustigman. 2009. Av-ASP-1, a Th1-biased protein adjuvant derived from the helminth Onchocerca volvulus, bind primarily to antigen-presenting cells and induces proinflammatory cytokines via the activation of toll-like receptors 2 and 4. J. Immunol, 182: 4005-4016.
  • Figueiredo, A. S., T. Höfer, C. Klotz, C. Sers, S. Hartmann, R. Lucius, P. Hammerstein. 2009. Modelling and simulating IL-10 production and regulation by macrophages after stimulation with an immunomodulator of parasitic nematodes. FEBS J., 276:3454-3469.
  • Lucius, R., S. Hartmann. 2009. Parasiten als Immunologen: Weshalb hemmen Würmer Allergien? Biol.Unserer Zeit, 39:84-90.
  • Lucius, R. C. Schnöller, S. Hartmann. 2009. Würmer als Wohltäter? Ein Parasitenprotein blockiert Allergien. Humboldt-Spektrum 1/2009.
  • Schnöller, C., S. Rausch, S. Pillai, A. Avagyan, B. Wittig, C. Loddenkemper, A. Hamann, E. Hamelmann, R. Lucius, S. Hartmann. 2008. A helminth immunomodulator reduces allergic and inflammatory responses by induction of IL-10-producing macrophages. J. Immunol., 180: 4265-4272.
  • Rausch, S., J. Huehn, D. Kirchhoff, J. Rzepecka, C. Schnöller, S. Pillai, C. Loddenkemper, A. Scheffold, A. Hamann, R. Lucius, S. Hartmann. 2008. Interaction of effector and regulatory T cells in a parasitic nematode infection. Infect. Immun., 76: 1908-1919.
  • Lendner M., R. Lucius, S. Hartmann. 2008. RNA interference in Heligmosomoides polygyrus: new aspects; Mol. Biochem. Parasitology, 16: 21-31.
  • Sereda M.J., S. Hartmann, R. Lucius. 2008. Helminhs and allergy: the example of tropomyosin. Trends Parasitol., 24: 272-278.
  • Dahten, A., C. Koch, D. Ernst, C. Schnöller, S. Hartmann, M. Worm. 2008. Systemic PPARg ligation inhibits allergic immune response in the skin. J. Invest. Dermatol., 128: 2211-2218.
  • Kirchhoff, D., M. Frentsch, P. Leclerk, D. Bumann, S. Rausch, S. Hartmann, A. Thiel, A. Scheffold. 2007. Identification and isolation of murine antigen-reactive T cells according to CD154 expression. Eur. J. Immunol., 37: 2370-2377.
  • Hartmann, S., M. Sereda, A. Sollwedel, B. Kalinna, Lucius R. 2006. A nematode allergen elicits protection against challenge infection under specific conditions. Vaccine, 24: 3581-3590.
  • Rzepecka, J., R. Lucius, M. Doligalska, S. Beck, S. Rausch, S. Hartmann. 2006. Studies on screening for immunomodulatory proteins of the intestinal parasitic nematode Heligmosomoides polygyrus. Parasite Immunology, 28: 463-472.
  • Rajakumar, S, W. Bleiss, S. Hartmann, P. Schierack, A. Marko, R. Lucius. 2006. Concomitant immunity in a rodent model of filariasis, the infection of Meriones unguiculatus with Acanthocheilonema viteae. Parasitology, 92: 41-45.
  • Pillai, S., B. Kalinna, E. Liebau, S. Hartmann, F. Theuring, R. Lucius. 2005. Studies on Acanthocheilonema viteae cystatin: Genomic organization, promoter studies and expression in C. elegans. Filaria Journal, 4: 9-19.
  • Hartmann, S., R. Lucius. 2003. Modulation of host immune responses by nematode cystatins. Int. J. Parasitol., 33: 1291-1302.
  • Schierack, P., R. Lucius, B. Sonnenburg, K. Schilling, S. Hartmann. 2003. Parasite specific immunomodulatory functions of filarial cystatin. Infect. Immun., 71: 2422-2429.
  • Hartmann, S., A. Sollwedel, A. Hoffmann, B. Sonnenburg, R. Lucius. 2003. Characterization of IgE responses in a rodent model of filariasis and the allergenic potential of filarial antigens using an in vitro assay. Parasite Immunol., 25: 9-16.
  • Drabner, B., U. Reineke, J. Schneider-Mergener, R. E. Humphreys, S. Hartmann, R. Lucius. 2002. Identification of T helper cell-recognized epitopes in the chitinase of the filarial nematode Onchocerca volvulus. Vaccine, 20: 3685-3694.
  • Hartmann, S., A. Schönemeyer, B. Sonnenburg, B. Vray, R. Lucius. 2002. Cystatins of filarial nematodes up-regulate the nitric oxide production of interferon-g-activated murine macrophages. Parasite Immunol., 24: 253-262.
  • Vray, B., S. Hartmann, J. Hoebeke. 2002. Immunomodulatory properties of cystatins. Cell. Mol. Life Sci., 59: 1503-1512.
  • Bleiss, W., U. Oberlander, S. Hartmann, R. Adam, A. Marko, A. Schonemeyer, R. Lucius. 2002. Protective immunity induced by irradiated third-stage larvae of the filaria Acanthocheilonema viteae is directed against challenge third-stage larvae before molting. J. Parasitol., 88: 264-270.
  • Schönemeyer, A., R. Lucius, B. Sonnenburg, N. Brattig, R. Sabat, K. Schilling, J. Bradley, S. Hartmann. 2001. Modulation of human T cell responses and macrophage functions by onchocystatin, a secreted protein of the filarial nematode Onchocerca volvulus . J. Immunol., 167: 3207-3215.
  • Lucius R., S. Hartmann. 2000. Molekulare und immunologische Adaptationen von Parasiten. Nova Acta Leopoldina, 316: 247-261.
  • Hartmann, S., B. Kyewski, B. Sonnenburg, R. Lucius. Eur. J. Immunol. 1997. A filarial cysteine protease inhibitor down-regulates T cell proliferation and enhances IL-10 production. Eur. J. Immunol., 27: 2253-2260.
  • Hartmann, S., R. Adam, T. Marti, Ch. Kirsten, S. Seidinger, R. Lucius. 1997. A 41-kDa antigen of the rodent filaria Acanthocheilonema viteae with homologies to tropomyoin induces host-protective immune responses. Parasitol. Res., 83: 390-393.
  • Verdot, L., G. Lalmanach, V. Vercruysse, S. Hartmann, R. Lucius, J. Hoebeke, F. Gauthier, B. Vray. 1996. Cystatins up-regulate nitrite oxide release from interferon-g activated mouse peritoneal macrophages. J. Biol. Chem., 271: 28077-28081.